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Medicinal Chemistry

Process R&D

Pharmaceutical Research

Molecular Building Blocks

Pharmacokinetics

Pre-formulation studies

Determine development strategy based on client development objectives (generic/innovative drugs/innovative formulations), conduct pre-prescribing studies, and determine feasibility of prescribing process.

Dissociation constant (pKa)
Partition/distribution coefficient (Log D/P)
Intrinsic solubility (S^o)
Biopharmaceutics classification system (BCS)
Formulation development with high bioavailability (amorphous/nanoparticle/nanoemulsion, etc.)
Solubility studies (water/pH1.2~pH12 solution/organic solvent/simulated intestinal fluid FaSSIF/FeSSIF/simulated gastric fluid FaSSGF/FeSSGF)
Stability (solution stability, solid stability, heat/light/acid/alkali/oxidation stability) and compatibility of raw materials and excipients

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